4,6-Bis[1-(4-hydroxyphenyl)-1-methylethyl]-1,3-benzenediol synthesis

Yield:147504-92-5 61.5%

Reaction Conditions:

with styrene-type strong acid ion exchange resin in ethyl acetate at 40; for 6 h;Reagent/catalyst;Solvent;Temperature;

Steps:

1-4 Example 1

Dissolve 15g 4-isopropenylphenol and its dimer in 100g ethyl acetate and stir for 20min; add 5.6g resorcinol, add 3.5g styrene-type strong acid ion exchange resin at 40; keep it warm for 6h; keep it warm After the completion, filter and wash the filter cake with 30g ethyl acetate; combine the washing and filtrate and extract 3 times with 600ml water; after the extraction, concentrate the ethyl acetate to obtain an oil (or solid), add 200g chloroform, and cool to -5 Stir and crystallize overnight at -0°C; filter and dry at 60°C to obtain 11.9 g of the product with a yield of 61.5%. The content is 98.7% checked by HPLC

References:

CN113307725,2021,A Location in patent:Paragraph 0031-0040