tert-Butyl 3-hydroxy-3-(2-methoxyphenyl)azetidine-1-carboxylate synthesis
- Product Name:tert-Butyl 3-hydroxy-3-(2-methoxyphenyl)azetidine-1-carboxylate
- CAS Number:1496354-73-4
- Molecular formula:C15H21NO4
- Molecular Weight:279.33
398489-26-4
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Yield:1496354-73-4 60%
Reaction Conditions:
Stage #1: 2-bromoanisolewith n-butyllithium in tetrahydrofuran;hexane at -78 - -60; for 0.583333 h;Inert atmosphere;
Stage #2: tert-butyl 3-oxoazetidine-1-carboxylate in tetrahydrofuran;hexane at -78; for 0.166667 h;Inert atmosphere;
References:
Allen, Lewis A. T.;Natho, Philipp;Parsons, Philip J.;Raclea, Robert-Cristian;White, Andrew J. P. [Journal of Organic Chemistry,2020,vol. 85,# 14,p. 9375 - 9385]