15-hexadecynoic acid synthesis
- Product Name:15-hexadecynoic acid
- CAS Number:99208-90-9
- Molecular formula:C16H28O2
- Molecular Weight:252.39
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Yield: 93%
Reaction Conditions:
with sodium amide in toluene at 20 - 120; for 9 h;Cooling with ice;
Steps:
3.2 Step 2,
In a 2000 ml three-necked flask equipped with a mechanical stirring device, add compound 2 (206 g, 0.5 mol) and 1200 ml toluene, and add sodium amide (78.0 g, 2 mol) in batches under ice-water bath cooling and continuous stirring. After the addition, the temperature was naturally raised to room temperature to react for 1 hour, and then slowly raised to 120°C and refluxed for 8 hours.After the reaction is completed, cool to room temperature, add 200ml of water to the reaction solution, adjust pH=2 with 6N HCl, separate the layers, wash the organic phase with brine (100ml) once, dry with sodium sulfate, and concentrate to obtain the product (compound 3) 117g , The yield is 93%.
References:
CN113582832, 2021, A Location in patent:Paragraph 0070; 0074-0076
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