(1-METHYL-1H-BENZOIMIDAZOL-2-YLSULFANYL)-ACETIC ACID synthesis
- Product Name:(1-METHYL-1H-BENZOIMIDAZOL-2-YLSULFANYL)-ACETIC ACID
- CAS Number:159222-24-9
- Molecular formula:C10H10N2O2S
- Molecular Weight:222.26
![methyl 2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetate](/CAS/20180703/GIF/86406-27-1.gif)
86406-27-1
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159222-24-9
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Yield:-
Reaction Conditions:
Stage #1: methyl (1-methyl-1H-benzimidazol-2-ylsulfanyl)acetatewith lithium hydroxide;water in tetrahydrofuran at 20;
Stage #2: with hydrogenchloride in tetrahydrofuran;water; pH=5 - 6;
Steps:
4
Compound 1-16 (step 1) (450mg, 1.9 mmol) was taken up in THF (5mL) and the LiOH (200mg, 4.76 mmol) in water (5mL) was added. The reaction stirred at room temperature overnight, was made slightly acidic (pH 5-6) with concentrated HCl, stripped to dryness and azeotroped from toluene to give the titled compound (1-16) as a mixture with in organic salts. Data for 1-16: ESI+ MS: 223[MH]+.
References:
WO2006/127550,2006,A1 Location in patent:Page/Page column 33; 34
3042-00-0
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159222-24-9
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$310.00/250mg
4760-34-3
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159222-24-9
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2360-22-7
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79-11-8
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159222-24-9
24 suppliers
$310.00/250mg