2-(2-AMINOPHENYL)-5-(4-(TERT-BUTYL)PHENYL)-1,3,4-OXADIAZOLE synthesis

Yield:159222-57-8 59%

Reaction Conditions:

with Eosin Y;potassium carbonate in dimethyl sulfoxide at 45; for 24 h;Sealed tube;Irradiation;

Steps:

Experimental Procedures for the Synthesis of 3aa-3ak, 3ba-3ga, 5a-5k.

General procedure: In sealed tube, a solution of 3 mL solvent (DMSO or DMF) of hydrazines 1 (0.5mmol), diketones 2 or 4 (0.5mmol), K₂CO₃ (1mmol), eosin Y (0.025mmol) was sequentially added. The reaction mixture was stirred under incandescent light (0.4 Wcm^-2) irradiation at 45 °C for 24 h. Then, the mixture extracted with ethyl acetate (3 × 10 mL), and the organic layer was combined and dried with anhydrous Na₂SO₄. After removal of the solvent under reduced pressure, the residue was separated by flash column chromatography to afford the pure product 3 or 5 (PE: EA = 20:1).

References:

Diao, Pinhui;Ge, Yanqin;zhang, Wenpei;Xu, Chen;Zhang, Nannan;Guo, Cheng [Tetrahedron Letters,2018,vol. 59,# 8,p. 767 - 770] Location in patent:supporting information