N-Des-t-boc-N-2-(1-hydroxy-2-methyl)propyloxycarbonxyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel synthesis

2synthesis methods

Product Name:N-Des-t-boc-N-2-(1-hydroxy-2-methyl)propyloxycarbonxyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel
CAS Number:160651-89-8
Molecular formula:C49H55Cl6NO19
Molecular Weight:1174.67

154044-74-3 Synthesis

Yield:160651-89-8 75%

Reaction Conditions:

with 2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane;water; for 1 h;Ambient temperature;

References:

Commercon, Alain;Bourzat, Jean-Dominique;Bezard, Daniel;Vuilhorgne, Marc [Tetrahedron,1994,vol. 50,# 34,p. 10289 - 10298]