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3-Cinnolinecarboxylic acid, 4-amino-8-fluoro-, hydrate synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
2: 93.6 percent / AlCl3 / chlorobenzene / 1 h / 100 - 110 °C
3: 72.1 percent / 80percent aq. H2SO4 / 80 - 100 °C

References:

Stanczak;Kwapiszewski;Lewgowd;Ochocki;Szadowska;Pakulska;Glowka [Pharmazie,1994,vol. 49,# 12,p. 884 - 889]

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