ChemicalBook CAS DataBase List 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-Benzofurancarboxylic acid

5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-Benzofurancarboxylic acid synthesis

6synthesis methods

Product Name:5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-Benzofurancarboxylic acid
CAS Number:163521-19-5
Molecular formula:C26H26N4O3
Molecular Weight:442.51

15861-24-2
431 suppliers
$10.00/5g

5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-Benzofurancarboxylic acid

163521-19-5
51 suppliers
inquiry

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 73 percent / isobutyl-AlCl₂ / CH₂Cl₂ / 15 - 30 °C
2: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h
3: K₂CO₃; Et₃N / acetonitrile / 12 h / Heating
4: KOH / methanol / 3 h / Heating

References:

Heinrich, Timo;Boettcher, Henning;Gericke, Rolf;Bartoszyk, Gerd D.;Anzali, Soheila;Seyfried, Christoph A.;Greiner, Hartmut E.;Van Amsterdam, Christoph [Journal of Medicinal Chemistry,2004,vol. 47,# 19,p. 4684 - 4692]

69604-00-8 Synthesis