Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 1-Methyl-β-carboline-3-carboxylic acid methyl ester
16641-82-0

1-Methyl-β-carboline-3-carboxylic acid methyl ester synthesis

9synthesis methods
1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-1-methyl-, methyl ester, (3S)-

191279-38-6
1 suppliers
inquiry

-

Yield:16641-82-0 96.5%

Reaction Conditions:

with potassium permanganate in tetrahydrofuran at 20;

Steps:

4.1.3. General procedure for the preparation of β-carboline-3-carboxylicacid methyl esters (4b and 4c)

General procedure: A suspension of the corresponding 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl esters (3b and 3c) (1 mmol) and 2.5 timesKMnO4 (2.5 mmol) in anhydrous THF (100 mL), the mixture was stirredfor 12 h at room temperature, remove the KMnO4 by filtration andevaporated the THF under reduced pressure to give the correspondingprocedure, the material was used without further purification for thefollowing steps.4.1.3.1. 1-Methyl-β-carboline-3-carboxylic acid methyl ester (4b).Intermediate 3b (1 g, 4.09 mmol) was oxidized according to thegeneral procedure to obtain the desired product 4b as white solid in96.5% yield, m.p.: 250-252 °C. ESI/MS m/z: 241.1 [M+H]+; 1H NMR(300 MHz, CDCl3) δ 8.81 (s, 1H), 8.58 (brs, 1H), 8.21 (d, J=7.8 Hz,2H), 7.60 (m, 2H), 7.38 (m, 1H), 4.07 (s, 3H), 2.92 (s, 3H).

References:

Zhao, Yifan;Ye, Feng;Xu, Jian;Liao, Qinghong;Chen, Lei;Zhang, Weijia;Sun, Haopeng;Liu, Wenyuan;Feng, Feng;Qu, Wei [Bioorganic and Medicinal Chemistry,2018,vol. 26,# 13,p. 3812 - 3824]