N-[N-[(1,1-DIMETHYLETHOXY)CARBONYL]-N-METHYL-L-ALANYL]-L-VALINE, METHYL ESTER synthesis
- Product Name:N-[N-[(1,1-DIMETHYLETHOXY)CARBONYL]-N-METHYL-L-ALANYL]-L-VALINE, METHYL ESTER
- CAS Number:178734-54-8
- Molecular formula:C15H28N2O5
- Molecular Weight:316.39
Yield:178734-54-8 84%
Reaction Conditions:
Stage #1: N-(tert-butoxycarbonyl)-N-methyl-L-alaninewith 4-methyl-morpholine;isobutyl chloroformate in tetrahydrofuran at 0; for 0.333333 h;
Stage #2: L-valine methylester hydrochloridewith 4-methyl-morpholine in tetrahydrofuran at 0; for 1 h;
References:
Hennessy, Edward J.;Adam, Ammar;Aquila, Brian M.;Castriotta, Lillian M.;Cook, Donald;Hattersley, Maureen;Hird, Alexander W.;Huntington, Christopher;Kamhi, Victor M.;Laing, Naomi M.;Li, Danyang;MacIntyre, Terry;Omer, Charles A.;Oza, Vibha;Patterson, Troy;Repik, Galina;Rooney, Michael T.;Saeh, Jamal C.;Sha, Li;Vasbinder, Melissa M.;Wang, Haiyun;Whitston, David [Journal of Medicinal Chemistry,2013,vol. 56,# 24,p. 9897 - 9919]