Cyclopropanecarboxaldehyde, 2-phenyl-, (1S,2R)- (9CI) synthesis
- Product Name:Cyclopropanecarboxaldehyde, 2-phenyl-, (1S,2R)- (9CI)
- CAS Number:186183-64-2
- Molecular formula:C10H10O
- Molecular Weight:146.19
29667-46-7
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186183-64-2
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Yield:186183-64-2 75%
Reaction Conditions:
with 4-methyl-2-morpholinone;tetra-n-propylammonium perruthenate. in dichloromethane at 20; for 3 h;Inert atmosphere;
Steps:
1.4 Step 4
To a solution of compound a4 (1.50g, 10.lmmol)dichioromethane (20m1) were added sequencially molecular sieve4A (5.Og), N-methylmorpholine oxide (2.95g, 25.3mmol) and tetrapropylammonium perruthenate (354mg, l.Olmmol) under argon atmosphere, and the mixture was stirred at room temperature for 3 hrs. The reaction mixture was filtered overcelite, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel, chromatography (hexane:ethyl acetate =5:1) to yield compound a5 (l.llg, 7.6lmmol,75%) as a colorless liquid.NMR data was consistent with the literature values.
References:
WO2014/10748,2014,A1 Location in patent:Paragraph 0187; 0191
140-29-4
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96847-52-8
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