2-Bromo-2-methyl-1-[4-(methylsulfonyl)phenyl]-1-propanone synthesis
- Product Name:2-Bromo-2-methyl-1-[4-(methylsulfonyl)phenyl]-1-propanone
- CAS Number:189955-79-1
- Molecular formula:C11H13BrO3S
- Molecular Weight:305.19
![2-Bromo-2-methyl-1-[4-(methylthio)phenyl]-1-propanone](/CAS/20200401/GIF/88324-55-4.gif)
88324-55-4
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Yield:189955-79-1 82%
Reaction Conditions:
with Oxone in chloroform;water;tert-butyl alcohol at 0 - 50;
Steps:
3 (3) Preparation of 2-methyl-1- (4-methanesulfonylphenyl) -2-bromo-1-propanone
The next product (0.3170 g) was dissolved in tert-butanol (3 mL) and trichloromethane (3 mL), cooled to 0 ° C and an aqueous solution of OXONE (1.06 g of OXONE dissolved in 10 mL of water) was added dropwise.Drop at 40 ~ 50 reaction 24 to 30 hours.TLC monitoring, the reaction is over.The reaction solution was diluted with EA (6 mL), the organic phase was separated and the aqueous phase was extracted with EA (3 x 3 mL). The organic phases were combined,2SO4Dried, filtered and dried to give a white solid in 82% yield.
References:
CN105859664,2016,A Location in patent:Paragraph 0014; 0015
53207-58-2
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![2-Methyl-1-[4-(Methylsulfonyl)phenyl]-1-propanone](/CAS/GIF/53207-59-3.gif)
53207-59-3
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100-68-5
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