ChemicalBook CAS DataBase List 2-Bromo-2-methyl-1-[4-(methylsulfonyl)phenyl]-1-propanone

2-Bromo-2-methyl-1-[4-(methylsulfonyl)phenyl]-1-propanone synthesis

4synthesis methods

Product Name:2-Bromo-2-methyl-1-[4-(methylsulfonyl)phenyl]-1-propanone
CAS Number:189955-79-1
Molecular formula:C11H13BrO3S
Molecular Weight:305.19

2-Bromo-2-methyl-1-[4-(methylthio)phenyl]-1-propanone

88324-55-4
4 suppliers
inquiry

2-Bromo-2-methyl-1-[4-(methylsulfonyl)phenyl]-1-propanone

189955-79-1
20 suppliers
inquiry

Yield:189955-79-1 82%

Reaction Conditions:

with Oxone in chloroform;water;tert-butyl alcohol at 0 - 50;

Steps:

3 (3) Preparation of 2-methyl-1- (4-methanesulfonylphenyl) -2-bromo-1-propanone

The next product (0.3170 g) was dissolved in tert-butanol (3 mL) and trichloromethane (3 mL), cooled to 0 ° C and an aqueous solution of OXONE (1.06 g of OXONE dissolved in 10 mL of water) was added dropwise.Drop at 40 ~ 50 reaction 24 to 30 hours.TLC monitoring, the reaction is over.The reaction solution was diluted with EA (6 mL), the organic phase was separated and the aqueous phase was extracted with EA (3 x 3 mL). The organic phases were combined,₂SO₄Dried, filtered and dried to give a white solid in 82% yield.

References:

CN105859664,2016,A Location in patent:Paragraph 0014; 0015

53207-58-2
42 suppliers
$56.00/25g

189955-79-1
20 suppliers
inquiry

References

53207-59-3 Synthesis

2-Methyl-1-[4-(Methylsulfonyl)phenyl]-1-propanone

53207-59-3
11 suppliers
$635.00/100mg

189955-79-1
20 suppliers
inquiry

References

100-68-5 Synthesis

100-68-5
333 suppliers
$9.00/1g

189955-79-1
20 suppliers
inquiry

References