Ethyl 3-(6,7-Dibromo-2,3-dihydro-1-benzofuran-5-yl)propanoate synthesis
- Product Name:Ethyl 3-(6,7-Dibromo-2,3-dihydro-1-benzofuran-5-yl)propanoate
- CAS Number:196597-75-8
- Molecular formula:C13H14Br2O3
- Molecular Weight:378.06
196597-66-7
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$89.00/100mg
196597-75-8
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$120.00/50mg
Yield:196597-75-8 96%
Reaction Conditions:
with bromine;sodium acetate in acetic acid at 17 - 18;Product distribution / selectivity;
Steps:
5
Sodium acetate (309.2 g, 3.76 moles) was added in a solution of Ethyl 3-(2,3- dihydrobenzofuran-5-yl)-2-propionate (783.5 g, 3.56 moles) obtained as per example 3 in acetic acid. The obtained solution was cooled to 17-18°C and to this, was added drop- wise 30% solution of bromine (3498 g, 21.85 moles) in acetic acid. The reaction mixture was stirred for 45 min and then added to a pre-cooled (10-150C) 15% aqueous solution of sodium sulfite (6054 g). The reaction mixture was stirred for 1 hour and the crystals obtained were filtered and washed with water to obtain 1294 g (yield: 96 %) of the title compound.
References:
WO2010/41271,2010,A2 Location in patent:Page/Page column 29
196597-67-8
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$600.00/1g
196597-75-8
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$120.00/50mg
496-16-2
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$7.00/5g
196597-75-8
27 suppliers
$120.00/50mg
![2,3-Dihydrobenzo[b]furan-5-carbaldehyde](/CAS/GIF/55745-70-5.gif)
55745-70-5
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$6.00/1g
196597-75-8
27 suppliers
$120.00/50mg
196597-65-6
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$90.00/250mg
196597-75-8
27 suppliers
$120.00/50mg