1H-Indole, 6-chloro-7-fluoro- synthesis
- Product Name:1H-Indole, 6-chloro-7-fluoro-
- CAS Number:259860-04-3
- Molecular formula:C8H5ClFN
- Molecular Weight:169.58
259860-07-6
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259860-04-3
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Yield:259860-04-3 63%
Reaction Conditions:
in diphenylether
Steps:
10 6-Chloro-7-fluoroindole
6-Chloro-7-fluoroindole A solution of 6-chloro-7-fluoroindole-2-carboxylic acid (2.1 g, 9.8 mmol) and diphenyl ether (30 mL) was heated under reflux for 4 h, cooled to room temperature and purified by column chromatography [SiO2; heptane-ethyl acetate (99:1 to 10:1)] to give the product (1.04 g, 63% yield) as a pale brown oil: IR νmax (Nujol)/cm-1 3460, 1573, 1490, 1446, 1201, 802 and 619; NMR δH (400 MHz, CDCl3) 6.44 (1H, brs) 7.04-7.09 (1H, m) 7.21-7.26 (1H, m) 7.30-7.34 (1H, m) and 8.40 (1H, brs).
References:
Vernalis Research Limited US6380238, 2002, B1
2106-49-2
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1826-67-1
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$51.29/100ml
259860-04-3
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2106-04-9
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$6.00/10g
259860-04-3
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259860-06-5
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259860-04-3
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