1H-Isoindol-1-one, 5,6-difluoro-2,3-dihydro- synthesis
- Product Name:1H-Isoindol-1-one, 5,6-difluoro-2,3-dihydro-
- CAS Number:1192040-50-8
- Molecular formula:C8H5F2NO
- Molecular Weight:169.13
1192040-49-5
0 suppliers
inquiry
1192040-50-8
13 suppliers
inquiry
Yield:1192040-50-8 10.6%
Reaction Conditions:
with triethylsilane;trifluoroacetic acid in dichloromethane at 20;
Steps:
293A
748 mg of 5,6-difluoro-3-hydroxy-2,3-dihydro-1H-isoindol-1-one (crude product, about 4.04 mmol) were initially charged in 50 ml of dichloromethane, 3.8 ml (48.5 mmol) of trifluoroacetic acid and 1.3 ml (8.08 mmol) of triethylsilane were added and the mixture was stirred overnight at RT. The reaction mixture was then concentrated, and the residue was dissolved in dichloromethane and washed with sodium bicarbonate solution. The crude product was purified by chromatography on silica gel (mobile phase cyclohexane/ethyl acetate 1:1 to 0:1). This gave 72 mg (10.6% of theory) of the target compound.LC-MS (method 15): Rt=0.61 min; m/z=170 (M+H)+.1H-NMR (400 MHz, DMSO-d6): δ=8.74 (br. s, 1H), 7.76-7.64 (m, 2H), 4.36 (s, 2H).
References:
US2011/34450,2011,A1 Location in patent:Page/Page column 114
18959-30-3
196 suppliers
$6.00/100mg
1192040-50-8
13 suppliers
inquiry
83684-73-5
76 suppliers
$60.00/500mg
1192040-50-8
13 suppliers
inquiry