1H-Pyrazole-3-carboxamide,4-amino-1-methyl-(9CI) synthesis
- Product Name:1H-Pyrazole-3-carboxamide,4-amino-1-methyl-(9CI)
- CAS Number:3920-40-9
- Molecular formula:C5H8N4O
- Molecular Weight:140.14
3920-39-6
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Yield:3920-40-9 96%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20; under 1551.49 Torr; for 18 h;
Steps:
69.3 4-Amino-1-methyl-pyrazole-3-carboxamide
1-Methyl-4-nitro-pyrazole-3-carboxamide (2.30 g, 13.5 mmol) was dissolved in methanol (50 mL), dry palladium on carbon (palladium 10%, water 1%, 230 mg) was added.
The reaction was allowed to react under 30 psi hydrogen pressure for 18 hours at room temperature, and then filtered.
The filtrate was concentrated under reduced pressure to give 4-amino-1-methyl-pyrazole-3-carboxamide (2.00 g, as a white solid) with a yield of 96%. MS-ESI calcd. [M + H]+ 141, found 141.
References:
EP3299371,2018,A1 Location in patent:Paragraph 0465; 0469
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