1H-Pyrazole-4-carboxamide,3-amino-1-methyl-(9CI) synthesis
- Product Name:1H-Pyrazole-4-carboxamide,3-amino-1-methyl-(9CI)
- CAS Number:89181-79-3
- Molecular formula:C5H8N4O
- Molecular Weight:140.14
21230-50-2
89181-79-3
GENERAL PROCEDURE: 1-methyl-3-amino-4-cyanopyrazole (0.03 mol) was dissolved in 7 mL of concentrated hydrochloric acid at 0°C and stirred at room temperature for 5 hours. After completion of the reaction, the mixture was poured into ice water and neutralized with 28% ammonia solution to pH 7. The precipitated white precipitate was washed with cold water and dried under vacuum.
21230-50-2
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89181-79-3
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Yield:89181-79-3 83%
Reaction Conditions:
with sulfuric acid at 0 - 20; for 5 h;
Steps:
4.3. General procedure for synthesis of 3-amino-1-(alkyl or arylalkyl)-1H-pyrazole-4-carboxamide (11-14)
General procedure: Carbonitriles 7-10 (0.03 mol) was dissolved in 7 mL concdH2SO4 at 0 C and stirred at room temperature for 5 h. Then thereaction mixture was poured into ice cold water and neutralizedto pH 7 with 28% NH3 solution. The white precipitate was formedwhich was further washed with cold water and dried undervacuum.
References:
Venkatesan, Gopalakrishnan;Paira, Priyankar;Cheong, Siew Lee;Vamsikrishna, Kosaraju;Federico, Stephanie;Klotz, Karl-Norbert;Spalluto, Giampiero;Pastorin, Giorgia [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 5,p. 1751 - 1765]