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2-(1,2,3,4-Tetrahydroisoquinolin-1-yl)aniline synthesis

8synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: pyridine / benzene / 20 °C
2: POCl3 / acetonitrile / Heating
3: SnCl2*2H2O / ethyl acetate / 30 h / Heating
4: 75 percent / sodium borohydride / methanol / 2 h / 20 °C

References:

Kuo, Chen-Yuan;Wu, Ming-Jung;Kuo, Yao-Haur [European Journal of Medicinal Chemistry,2006,vol. 41,# 8,p. 940 - 949]