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2-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE,& synthesis

4synthesis methods
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Yield:942-05-2 92%

Reaction Conditions:

Stage #1: 1-Naphthylacetamidewith [(aNHC)KN(SiMe3)2]2;4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane in toluene at 40; for 12 h;Inert atmosphere;Glovebox;Schlenk technique;
Stage #2: with water;sodium hydroxide in diethyl ether;toluene at 40; for 1 h;Inert atmosphere;Glovebox;Schlenk technique;
Stage #3: with hydrogenchloride in diethyl ether;water;Inert atmosphere;Glovebox;Schlenk technique;

References:

Bhunia, Mrinal;Sahoo, Sumeet Ranjan;Das, Arpan;Ahmed, Jasimuddin;Sreejyothi;Mandal, Swadhin K. [Chemical Science,2020,vol. 11,# 7,p. 1848 - 1854]