2(1H)-Pyrazinone,5-amino-3,6-dihydro-1-methyl- synthesis

Yield:623564-51-2 100%

Reaction Conditions:

with potassium carbonate in water at 0; for 0.666667 h;

Steps:

10.2

A solution of 5-amino-1-methyl-3, 6-dihydro-1 H-pyrazin-2-one hydrochloride (662mg) in methanol (10 mL) was added 10% potassium carbonate aqueous solution at On and then stirred for 40 min at OE]. The mixture was concentrated under reduced pressure. The residue was triturated with chloroform (18mL) and methanol (2 mL) at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The compound was obtained as a pale brown powder (515 mg, quantitative). 'H NMR (DMSO-d6) 6 2.88 (s, 3H), 3.94 (s, 2H), 4.42 (s, 2H).

References:

WO2003/93279,2003,A1 Location in patent:Page/Page column 72