2(1H)-pyridinone, 4,6-dimethyl-3-nitro- synthesis
- Product Name:2(1H)-pyridinone, 4,6-dimethyl-3-nitro-
- CAS Number:22934-13-0
- Molecular formula:C7H8N2O3
- Molecular Weight:168.15
Yield:-
Reaction Conditions:
with hydrogenchloride;sodium nitrite in water at 0 - 20;
Steps:
INTERMEDIATES 116 AND 117
-Amino-5-nitro-4,6-dimethylpyridine [22934-22-1] (1.43 g, 8.55 mmol) was dissolved in HC1 (15% in H20, 22.9 mL, 274 mmol) and then cooled to 0 °C. An aqueous solution of sodium nitrite (590 mg, 8.55 mmol) was added dropwise and the reaction mixture was stirred at 0 °C for 30 min, then at room temperature overnight. The mixture was extracted with CHCI3. The organic phase was dried (MgS04), filtered and evaporated in vacuo to afford a mixture of 1-116 and 1-117 (1.15 g, 80%).
References:
WO2019/243535,2019,A1 Location in patent:Page/Page column 65
16115-08-5
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