2-(2,2-Difluoroethoxy)ethanol synthesis
- Product Name:2-(2,2-Difluoroethoxy)ethanol
- CAS Number:853005-07-9
- Molecular formula:C4H8F2O2
- Molecular Weight:126.1
Yield:853005-07-9 99.2 %
Reaction Conditions:
with sodium hydroxide at 140;Reagent/catalyst;
Steps:
1-2
Take 4.7g of compound D1 (57.2mmol, 1.0eq), 3.4g of compound F (38.9mmol, 0.68eq) to dissolve in 15g of tetraethylene glycol dimethyl ether, and then add 0.16g NaOH (4.0mmol, 0.07eq), raise the temperature to 140°C, stir the reaction for 6h, naturally reduce to room temperature, filter, take the filtrate, use a water pump to distill under reduced pressure, collect 80-85°C fractions, The target compound was 4.87g, with a yield of 99.2% and a purity of 99.6%.
References:
CN115260011,2022,A Location in patent:Paragraph 0050-0065
96-49-1
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