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ChemicalBook CAS DataBase List 2-[2-(2-thienyl)ethyl]benzoic acid
1622-54-4

2-[2-(2-thienyl)ethyl]benzoic acid synthesis

6synthesis methods
Use thiophene to react with formaldehyde and concentrated hydrochloric acid, and then react with triethyl phosphite to finally obtain 2-[2-(2-thienyl)ethyl]benzoic acid.
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Yield:1622-54-4 80%

Reaction Conditions:

with sodium hydroxide;hydrogen;palladium on activated charcoal at 100; under 15200 Torr; for 12 h;

References:

Murty;Ramalingam;Sabitha;Yadav [Heterocyclic Communications,2001,vol. 7,# 5,p. 449 - 454]