2-(2,3-DIFLUORO-PHENYL)-1H-IMIDAZO[4,5-C]PYRIDINE synthesis
- Product Name:2-(2,3-DIFLUORO-PHENYL)-1H-IMIDAZO[4,5-C]PYRIDINE
- CAS Number:858935-15-6
- Molecular formula:C12H7F2N3
- Molecular Weight:231.2
54-96-6
364 suppliers
$5.00/100mg
4519-39-5
291 suppliers
$6.00/1g
858935-15-6
20 suppliers
$65.00/10mg
Yield:858935-15-6 88%
Reaction Conditions:
with PPA at 180; for 4 h;
Steps:
374.a
A mixture of 3, 4-diaminopyridine (2.00 g), 2,3-difluorobenzoic acid (1 equivalent) and polyphosphoric acid (50 g) was heated at 180 C for 4 h with stirring. Then the mixture was cooled to ambient temperature and poured into ice/water. The resulting mixture was neutralized by addition of solid NaOH. The crude 2- (2, 3- difluorophenyl)-1 (3) H-imidazo [4,5-c] pyridine was collected by filtration, washed with water and dried. It was used in the next step without further purification. Yield: 88%.
References:
WO2005/63744,2005,A2 Location in patent:Page/Page column 210