2-[2-(4-Bromophenyl)-2-Oxoethyl]Propanedinitrile synthesis

Yield:26454-82-0 82%

Reaction Conditions:

with potassium hydroxide in water;N,N-dimethyl-formamide at 20; for 2 h;

Steps:

Typical procedure for the alkylation of CH acids 1-3, 8, 10a, 10b, and 13-15.

General procedure: To a solution of 10 mmol of CH acid 1-3, 8, 10a, 10b, or 13-15 in 20 ml of DMF we added under stirring at 20°C 5.6 mL (10 mmol) of 10% aqueous potassium hydroxide and then 10 mmol of alkylating agent 4a-4c or 5. The mixture was stirred for 2 h and diluted with an equal volume of water, and the precipitate was filtered off and washed with water, ethanol, and hexane. In the synthesis of 6a, 6b, 11, 16a, and 16b, 11.2 mL (20 mmol) of 10% aqueous potassium hydroxide and 20 mmol of phenacyl bromide 4a or 4b were used.

References:

Dyachenko;Pavlova [Russian Journal of Organic Chemistry,2015,vol. 51,# 12,p. 1693 - 1696][Zh. Org. Khim.,2015,vol. 51,# 12,p. 1728 - 1731,4]