2-(2,4-difluorophenyl)oxirane synthesis
- Product Name:2-(2,4-difluorophenyl)oxirane
- CAS Number:111991-12-9
- Molecular formula:C8H6F2O
- Molecular Weight:156.13
102429-07-2
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$19.00/1g
111991-12-9
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Yield:111991-12-9 66%
Reaction Conditions:
Stage #1: 2-bromo-2',4'-difluoroacetophenonewith sodium tetrahydroborate in methanol at 10 - 20; for 1 h;
Stage #2: with potassium carbonate at 20; for 1 h;
Steps:
I.19
Intermediate 192-(2,4-Difluorophenyl)oxiraneSodium borohydride (0.367 g, 10.85 mmol) was added to a stirred solution of 2-bromo- 2',4'-difluoroacetophenone ([CAS 102429-07-2], 5.1 g, 21.7 mmol) in MeOH (152 mL) at 10 °C. The mixture was stirred at RT for 1 h. Then, K2C03 (4.499 g, 32.55 mmol) was added and the mixture was stirred at RT for 1 h. The mixture was filtered through diatomaceous earth and the filtrate was concentrated in vacuo. The residue was treated with water and extracted with CH2C12/THF. The organic layer was separated, dried (Na2S04), filtered and the solvents evaporated in vacuo to yield 1-19 (2.24 g, 66%) as a yellow oil.
References:
WO2012/62759,2012,A1 Location in patent:Page/Page column 45
399-53-1
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51336-94-8
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