2,2'-Diamino-4,4'-bithiazole synthesis
- Product Name:2,2'-Diamino-4,4'-bithiazole
- CAS Number:58139-59-6
- Molecular formula:C6H6N4S2
- Molecular Weight:198.27
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Yield: 5.9 g
Reaction Conditions:
in ethanol for 2 h;Reflux;
Steps:
1.1 (1) Preparation of 2,2'-diamino-4,4'-bithiazole (the compound of the formula 2)
In a three-necked flask equipped with a reflux condenser and a stirring device,9.0 g (0.036 mol) of 1,4-dibromobutanedione were added in sequence,5.4g (0.072mol) thioureaAnd 200mL of absolute ethanol, refluxed under stirring for 2h,The reaction mixture is then poured into 100 mL of hot water (45-50 ° C).Concentrated aqueous ammonia (22-25%) was added to the mixture under stirring to pH 8-9, and a pale yellow precipitate was allowed to stand, which was filtered to give a crude product.The crude product was recrystallized from a mixed solvent of ethanol/water (3:1 by volume) and dried to give the product 2,2'-diamino-4,4'-bithiazole 5.9 g.
References:
Shanxi Datong University;Jia Zhifang;Wang Kewei;Liu Huijun;Guo Ying;Guo Yong;Feng Feng CN109134454, 2019, A Location in patent:Paragraph 0012; 0036; 0038; 0039
17356-08-0
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6305-43-7
72 suppliers
$39.00/1g
58139-59-6
70 suppliers
$41.00/50 mg