2,2-DiMethoxy-N-(thiophen-3-ylMethyl)ethanaMine synthesis
- Product Name:2,2-DiMethoxy-N-(thiophen-3-ylMethyl)ethanaMine
- CAS Number:58754-97-5
- Molecular formula:C9H15NO2S
- Molecular Weight:201.29
Yield:58754-97-5 94%
Reaction Conditions:
Stage #1: 3-thiophene carboxaldehyde;2,2-dimethoxyethylamine at 20; for 60 h;
Stage #2: with hydrogen;palladium 10% on activated carbon in ethanol; under 2896.11 Torr;
Steps:
1
To 3-thiophenecarboxaldehyde (8.75 mL) cooled to 0° C. was added aminoacetaldehyde dimethylacetal (14.2 mL). The clear solution was stirred at room temperature for 60 h. The solution was diluted with ethanol and hydrogenated at 56 psi in the presence of 10% Pd/C (5 g) overnight. The catalyst was filtered off and washed with MeOH. The solvent was removed by rotary evaporation and co-evaporated with toluene to afford an oil (19 g, 94% yield).
References:
US2004/14755,2004,A1 Location in patent:Page/Page column 76
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