ChemicalBook CAS DataBase List 2,2-DIMETHYLTETRAHYDROFURAN

2,2-DIMETHYLTETRAHYDROFURAN synthesis

10synthesis methods

Product Name:2,2-DIMETHYLTETRAHYDROFURAN
CAS Number:1003-17-4
Molecular formula:C6H12O
Molecular Weight:100.16

22508-64-1
41 suppliers
$45.00/10mg

1003-17-4
30 suppliers
$857.41/5G

Yield:1003-17-4 96%

Reaction Conditions:

with calcium(II) bis(trifluoromethanesulfonyl)imide;tert-butylammonium hexafluorophosphate(V) in dichloromethane at 20; for 2 h;

Steps:

General procedure for the Hydroalkoxylation
General procedure: The alcohol (0.25 mmol) is dissolved in 2 ml of dichloromethane. Bu4NPF6 (5 mol%) and Ca(NTf2)2 (5 mol%) are added at indicated temperature and stirred until conversion of the alcohol is complete (monitored by TLC and/or GC). For the isolation of the product, 5 mL sat. NaHCO3-solution is added, the aqueous phase extracted with dichloromethane, the combined organic phases dried over Na2SO4 and concentrated in vacuo. The crude product is purified by column chromatography.

References:

Kena Diba, Anastasie;Begouin, Jeanne-Marie;Niggemann, Meike [Tetrahedron Letters,2012,vol. 53,# 49,p. 6629 - 6632,4] Location in patent:supporting information Kena Diba, Anastasie;Begouin, Jeanne-Marie;Niggemann, Meike [Tetrahedron Letters,2012,vol. 53,# 49,p. 6629 - 6632] Location in patent:supporting information

FullText

5891-21-4 Synthesis