ChemicalBook CAS DataBase List 2-(3,4-Dimethoxyphenyl)ethanol

2-(3,4-Dimethoxyphenyl)ethanol synthesis

12synthesis methods

Product Name:2-(3,4-Dimethoxyphenyl)ethanol
CAS Number:7417-21-2
Molecular formula:C10H14O3
Molecular Weight:182.22

93-40-3
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$10.00/5g

7417-21-2
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$29.00/5g

Yield:7417-21-2 98.9%

Reaction Conditions:

with sodium tetrahydroborate;iodine in tetrahydrofuran at 20; for 0.583333 h;Cooling with ice;Concentration;

Steps:

1.5 (5) Synthesis of Compound 22

Take a dry and clean 100 mL round bottom flask, accurately weigh sodium borohydride (0.4 g, 7.65 mmol) and iodine (1.3 g, 5.10 mmol) in a bottle, add 10 mL of tetrahydrofuran, place in an ice bath, stir After 5 min, 21 (1.0 g, 5.10 mmol) was added in small portions. After the addition, the ice bath was removed and the reaction was carried out at room temperature. The reaction was monitored by TLC. After 30 min, the reaction was completed by TLC. 50 ml of a 5% sodium hydroxide solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate (10 mL × 3), and the organic phase was combined and washed with brine (10 mL × 3). The organic phase was separated, dried over anhydrous sodium sulfate, filtered and evaporatedThe title compound (22) was obtained as a yellow oil.The yield was 98.9%.

References:

CN108484593,2018,A Location in patent:Paragraph 0050; 0051; 0065