2,3-BIS-BROMOMETHYL-1,4-DIMETHOXY-BENZENE synthesis
- Product Name:2,3-BIS-BROMOMETHYL-1,4-DIMETHOXY-BENZENE
- CAS Number:19164-83-1
- Molecular formula:C10H12Br2O2
- Molecular Weight:324.01
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Yield: 99%
Reaction Conditions:
with N-Bromosuccinimide;dibenzoyl peroxide in tetrachloromethane at 65; for 4 h;
Steps:
2 Step 2
To a magnetically stirred solution of 1,4-dimethoxy-2,3-dimethyl-benzene (13.90 g, 83.6 mmol) in carbon tetrachloride (300 mL) at room temperature was added N-bromosuccinimide (32.2 g, 176 mmol) in one portion, and the reaction mixture was heated up to 65°C. Benzoyl peroxide (0.54 g, 2.23 mmol) was added at 65°C, and the reaction mixture stirred for further 4 hours before cooling down to 55°C. The reaction mixture was filtered, the solid washed with carbon tetrachloride, and the combined filtrates were concentrated in vacuo to yield 2,3-bis(bromomethyl)-1,4-dimethoxy-benzene (26.8 g, 82.7 mmol) in 99% yield.
References:
Bioversys AG;Schneider, Peter;Riedl, Rainer;Tigges, Marcel;Gitzinger, Marc;Pieren, Michel;Levi, Assaf;Sephton, Mark;Schellhorn, Birgit;Züger, Patrik;Brand, Michael;Gygax, Daniel;Spies, Peter EP2762134, 2014, A1 Location in patent:Paragraph 0105-0106
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