2-(3-broMo-2,6-diMethylphenyl)acetic acid synthesis
- Product Name:2-(3-broMo-2,6-diMethylphenyl)acetic acid
- CAS Number:197711-04-9
- Molecular formula:C10H11BrO2
- Molecular Weight:243.1
938-50-1
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Yield:197711-04-9 89.9%
Reaction Conditions:
with bromine;acetic acid at 45; for 17 h;Product distribution / selectivity;
Steps:
6
At 45° C., a solution of 62.5 g [391 mmol] of bromine in 120 ml of glacial acetic acid is added dropwise over a period of 1 hour to a solution of 47.6 g [290 mmol] of 2,6-dimethylphenylacetic acid in 300 ml of glacial acetic acid. The reaction mixture is then stirred at 45° C. for another 16 hours and concentrated on a rotary evaporator. The solid obtained is stirred in 180 ml of methylcyclohexane at room temperature for 4 hours. After filtration, the residue is washed twice with in each case 60 ml of methylcyclohexane and then dried. This gives 64.9 g of a solid. GC(sil.) analysis: 97.7% pure (89.9% of theory).
References:
US2012/116118,2012,A1 Location in patent:Page/Page column 9
98-19-1
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