2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane synthesis
- Product Name:2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane
- CAS Number:77771-04-1
- Molecular formula:C9H8BrFO2
- Molecular Weight:247.06
107-21-1
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77771-02-9
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77771-04-1
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Yield:77771-04-1 81.5%
Reaction Conditions:
with toluene-4-sulfonic acid in toluene at 20; for 18 h;
Steps:
280.1 [Step 1] Synthesis of 2-(3-bromo-4-fluorophenyl)-l,3-dioxolane
3-bromo-4-fluorobenzaldehyde (10.500 g, 51.722 mmol), PTSA (0.098 g, 0.517 mmol) and ethylene glycol (3.471 mL, 62.066 mmol) were dissolved in toluene (50 mL) at room temperature, after which the resulting solution was stirred at the same temperature for 18 hours. Water was poured into the reaction mixture and an extraction was performed with dichloromethane. An organic layer was washed with saturated sodium chloride aqueous solution, dehydrated with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting concentrate was purified via column chromatography (S1O2, 24 g cartridge; ethyl acetate/hexane = 0 to 20%) and concentrated to obtain 2-(3-bromo-4- fluorophenyl)-l,3-dioxolane (10.420 g, 81.5%) in a yellow oil form.
References:
WO2022/13728,2022,A1 Location in patent:Page/Page column 259
77771-02-9
396 suppliers
$15.00/25g
77771-04-1
25 suppliers
$59.00/1g
7381-30-8
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77771-02-9
396 suppliers
$15.00/25g
77771-04-1
25 suppliers
$59.00/1g