2-(3-bromo-5-methoxyphenyl)ethanamine synthesis
- Product Name:2-(3-bromo-5-methoxyphenyl)ethanamine
- CAS Number:262450-67-9
- Molecular formula:C9H12BrNO
- Molecular Weight:230.1
123018-27-9
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Yield:262450-67-9 34.4%
Reaction Conditions:
with ammonium hydroxide in methanol; under 2585.81 Torr;Inert atmosphere;
Steps:
Preparation of compound 80-3
Compound 80-2 (1.2 g, 5.31 mmol) was dissolved in methanol (8 mL) in an autoclave at room temperature, Raney nickel (1.0 g) and concentrated ammonia (8 mL) were added. The reaction mixture was stirred overnight under a hydrogen atmosphere (50 psi). After pressure relief, the reaction solution was filtered and concentrated in vacuo to obtain compound 80-3 (420 mg, crude yield 34.4%) as a yellow oil, which was directly used in the next reaction.
References:
WO2022/63278,2022,A1 Location in patent:Page/Page column 69-70
59297-29-9
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