2,3-DiaMino-6-chlorobenzonitrile synthesis

Yield:-

Reaction Conditions:

with hydrogen;acetic acid;5%-palladium/activated carbon under 15201 Torr; for 16 h;

Steps:

2.ii (ii) 2, 3-Diamino-6-chlorobenzonitrile
2-Amino-6-chloro-3-nitrobenzonitrile (8g) in acetic acid (100ML) was treated with 5% palladium on carbon (LG) and the mixture hydrogenated at 20 atmospheres for 16HRS. The catalyst was filtered off and the acetic acid removed in vacuo to give 2,3-diamino-6- chlorobenzonitrile. 1H NMR (D6-DMSO) : 8 6.63 (1H, dd), 6.55 (1H, dd), 5.73 (2H, broad s), 5.13 (2H, broad s).

References:

ASTRAZENECA AB WO2004/99190, 2004, A1 Location in patent:Page 19-20

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