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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 2,3-DIFLUORO-6-NITROTOLUENE
914348-35-9

2,3-DIFLUORO-6-NITROTOLUENE synthesis

1synthesis methods
141428-47-9 Synthesis
2-(2,3-Difluoro-6-nitrophenyl)acetic acid

141428-47-9
55 suppliers
$60.00/1g

Benzeneacetic acid, 2,3-difluoro-4-nitro-

932373-71-2
0 suppliers
inquiry

932373-72-3 Synthesis
2,3-Difluoro-1-Methyl-4-nitrobenzene

932373-72-3
51 suppliers
$32.00/1g

2,3-DIFLUORO-6-NITROTOLUENE

914348-35-9
74 suppliers
$72.00/100mg

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Yield:-

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 50; for 0.5 h;

Steps:

17
The mixture of 2,3-difluoro-4-nitrophenylacetic acid and 2,3-difluoro-6-nitrophenylacetic acid from D16 (13.5g) was dissolved in dimethylformamide (100ml) and potassium carbonate (8.5g) added. After stirring at 5O0C for 30min the cooled solution was partitioned between aqueous hydrochloric acid and hexane. Drying (MgSO4), evaporation, and chromatography (0-5% ethyl acetate in hexane, 7Og silica column) gave 3.2g of a 3:1 mixture of the title compound and 2,3-difluoro-6-nitrotoluene. EPO 1H NMR δ (DMSO, 400 MHz): 2.4 and 2.5 (3H1 m), 7.3 and 7.6 (1H, 2 m), 7.9 (1H, m).

References:

GLAXO GROUP LIMITED WO2007/36715, 2007, A2 Location in patent:Page/Page column 48-49

2,3-DIFLUORO-6-NITROTOLUENE Related Search:

2-(2,3-Difluoro-6-nitrophenyl)acetic acid 5-NITRO-2,3,4,5-TETRAFLUORO BENZOYL CHLORIDE