2,3-DIMETHYL-4-(TRIFLUOROMETHYLTHIO)PHENOL synthesis

Yield:-

Reaction Conditions:

titanium tetrachloride in dichloromethane;water;

Steps:

VII.d.13 4-Trifluoromethylmercapto-2,3-dimethylphenol by TiCl4 catalysis

EXAMPLE VIId-13 4-Trifluoromethylmercapto-2,3-dimethylphenol by TiCl₄ catalysis 100 g of 2,3-dimethylphenol were initially introduced into 500 ml of dichloromethane and 10 ml of titanium tetrachloride were added. 50 g of trifluoromethylsulphenyl chloride were then introduced at 20° C. and the mixture was subsequently stirred for 3 hours. 100 ml of water were then stirred in, the phases were separated and the organic phase was distilled. After a forerun, consisting of dimethylphenol and product, 68 g of product distilled at 85°-88° C./6 mbar.

References:

US4956370,1990,A