2-(3-PHENYL-[1,2,4]OXADIAZOL-5-YL)-ETHYLAMINE synthesis

2synthesis methods

Product Name:2-(3-PHENYL-[1,2,4]OXADIAZOL-5-YL)-ETHYLAMINE
CAS Number:805184-96-7
Molecular formula:C10H11N3O
Molecular Weight:189.21

Carbamic acid, N-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl]-, 1,1-dimethylethyl ester

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2-(3-PHENYL-[1,2,4]OXADIAZOL-5-YL)-ETHYLAMINE

805184-96-7
18 suppliers
$84.00/200μmol

Yield:805184-96-7 79%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20;

Steps:

Intermediate 1. 2-(3 -phenyl- 1 ,2,4-oxadiazol-5 -yl)ethanamine

Intermediate 1[00169] To a suspension of Intermediate 1A (1.2 g, 4.2 mmol) in DCM (1 1 mL) was added TFA (11 mL). The reaction mixture was stirred at rt for several hours. The reaction mixture was diluted with CH₂CI₂, and washed with saturated aHC0₃ then brine. The aqueous phases were extracted with CH₂CI₂ (3x), and the combined organic portions dried over Na₂S0₄, filtered, and concentrated to give Intermediate 1(623 mg, 79% yield). HPLC/MS (Method C) retention time = 1.43 min, [M+H]+ 190.2 ; 1H NMR (500 MHz, chloroform-i/) (δ ppm): 1.63 (br s, 2 H), 3.09 (t, J=6.32 Hz, 2 H), 3.25 (t, J=6.32 Hz, 2 H), 7.46-7.53 (m, 3 H), 8.08 (d, J=6.05 Hz, 2 H).

References:

WO2013/48928,2013,A1 Location in patent:Paragraph 00169

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805184-96-7
18 suppliers
$84.00/200μmol

References

2-(3-PHENYL-[1,2,4]OXADIAZOL-5-YL)-ETHYLAMINE Related Search:

Oxolamine