2,4(1H,3H)-Pyrimidinedione, 6-(2-phenylethyl)- synthesis

2synthesis methods

Product Name:2,4(1H,3H)-Pyrimidinedione, 6-(2-phenylethyl)-
CAS Number:13345-12-5
Molecular formula:C12H12N2O2
Molecular Weight:216.24

4(1H)-Pyrimidinone, 2,3-dihydro-6-(2-phenylethyl)-2-thioxo-

656822-33-2
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2,4(1H,3H)-Pyrimidinedione, 6-(2-phenylethyl)-

13345-12-5
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Yield:13345-12-5 34%

Reaction Conditions:

Stage #1: 6-ethylphenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-onewith chloroacetic acid in tetrahydrofuran; for 6 h;Heating;
Stage #2: with hydrogenchloride in tetrahydrofuran; for 12 h;Heating;

References:

Rodriguez, Alice L.;Tamrazi, Anobel;Collins, Margaret L.;Katzenellenbogen, John A. [Journal of Medicinal Chemistry,2004,vol. 47,# 3,p. 600 - 611]

17071-29-3 Synthesis

3-OXO-5-PHENYL-PENTANOIC ACID ETHYL ESTER

17071-29-3
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$175.00/50mg

13345-12-5
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References