2,4,5-TRIFLUOROBENZENESULFONAMIDE synthesis
- Product Name:2,4,5-TRIFLUOROBENZENESULFONAMIDE
- CAS Number:287172-63-8
- Molecular formula:C6H4F3NO2S
- Molecular Weight:211.16
220227-21-4
287172-63-8
General procedure for the synthesis of 2,4,5-trifluorobenzenesulfonamides from 2,4,5-trifluorobenzenesulfonyl chloride: ammonium hydroxide (NH4OH, 910 mg, 26 mmol) was slowly added to a solution of 2,4,5-trifluorobenzene-1-sulfonyl chloride (3.0 g, 13 mmol) in tetrahydrofuran (THF, 30 mL). The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure to afford 2,4,5-trifluorobenzenesulfonamide (2.7 g, 13 mmol, 98% yield) as a yellow solid. The product was analyzed by electrospray ionization mass spectrometry (ESI-MS) and showed a molecular ion peak (EI+, m/z): 211.9 [M+H]+.
220227-21-4
117 suppliers
$6.00/1g
287172-63-8
44 suppliers
$11.00/250mg
Yield:287172-63-8 98%
Reaction Conditions:
with ammonium hydroxide in tetrahydrofuran at 20;
Steps:
13.1 Step 1: 2,4,5-trifluorobenzenesulfonamide
To a solution of 2,4,5-trifluorobenzene-1-sulfonyl chloride (3.0 g, 13 mmol), in THF(30 mL) was added NH4OH (910 mg, 26 mmol) and the solution was stirred for 14 h at rt. The solution was concentrated in vacuo to afford 2,4,5-trifluorobenzenesulfonamide (2.7 g, 13 mmol, 98%) as a yellow solid. ESI-MS (EI+, m/z): 211.9 [M+H]t
References:
WO2018/89433,2018,A1 Location in patent:Paragraph 00411