[2,4,5-tris(hydroxymethyl)phenyl]methanol synthesis
- Product Name:[2,4,5-tris(hydroxymethyl)phenyl]methanol
- CAS Number:1204-76-8
- Molecular formula:C10H14O4
- Molecular Weight:198.22
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Yield:1204-76-8 1.2 g
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 0;Reflux;
Steps:
3 Preparation of 1,2,4,5-tetrahydroxymethylbenzene (Route 1)
3.04g (80mmol) lithium aluminum hydride and 30ml tetrahydrofuran were added to the 250ml reaction flask,Stir and cool down to 0°C,Then, a solution of 6.2 g (20 mmol) of tetramethyl 1,2,4,5-benzenetetracarboxylate and 60 ml of tetrahydrofuran was added dropwise, and the reaction was carried out under reflux overnight.After cooling to room temperature, 3ml water was added dropwise to quench the reaction,Then add 50 ml (15% W/M) sulfuric acid solution, stir for 30 minutes, extract twice with dichloromethane, combine the organic phase and dry with anhydrous sodium sulfate, recrystallize with n-hexane/ethyl acetate after rotary evaporation to obtain 1.2 g of solid.
References:
CN114957327,2022,A Location in patent:Paragraph 0014-0015; 0034-0037
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