2,4,6-TRIS(4-BROMOPHENYL)-1,3,5-TRIAZINE synthesis
- Product Name:2,4,6-TRIS(4-BROMOPHENYL)-1,3,5-TRIAZINE
- CAS Number:30363-03-2
- Molecular formula:C21H12Br3N3
- Molecular Weight:546.05
623-00-7
30363-03-2
(1) Synthesis of 2,4,6-tris(4-bromophenyl)-1,3,5-triazine: Trifluoromethanesulfonic acid (66.6 mmol, 9.99 g) was added to a dry two-necked flask under the protection of nitrogen and the flask was cooled down to 0 to 5°C in an ice bath. Subsequently, 4-bromobenzonitrile (19.6 mmol, 3.57 g) was slowly added and stirred continuously for 30 minutes at this temperature. After that, the reaction mixture was transferred to room temperature condition and continued stirring for 12 hours. After completion of the reaction, an appropriate amount of water was added to the mixture and neutralized with sodium hydroxide solution to neutral. Next, the organic layer was separated by extraction with a solvent mixture of chloroform and acetone (1:1, v/v). The organic layer was dried over anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure to give the white solid product 2,4,6-tris(4-bromophenyl)-1,3,5-triazine (yield: 3.34 g, yield: 93.6%).
![1-(tert-butyl)-3-((5-chloro-3-(hydroxymethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one](/CAS/20180629/GIF/1455358-11-8.gif)
1455358-11-8
26 suppliers
inquiry
30363-03-2
139 suppliers
$8.00/250mg
Yield:30363-03-2 75%
Reaction Conditions:
with bromine;iron;sodium hydroxide in chloroform;Cooling with ice;Darkness;
Steps:
3
Under ice bath and dark conditions,Add to a 500ml three-necked bottle2,4,6-triphenyl-1,3,5-triazine (17.84g, 100mmol),Iron powder (0.83g, 15mmol)And chloroform solvent (500ml),Bring liquid bromine (25.7ml, 500mmol)Add pre-filled 50mlIn the constant pressure funnel of chloroform,Slowly add the mixture dropwise,And use sodium hydroxide solution to treat bromine vapor.After reacting overnight,Add NaHSO3 aqueous solution to stop the reaction,After the system color becomes white,Separate the solids,And washed with methanol,Purify with chlorobenzene,The final product2,4,6-Tris(4-bromophenyl)-1,3,5-triazine(40.9g, yield 75%),
References:
CN113264951,2021,A Location in patent:Paragraph 0023; 0024; 0025
623-00-7
490 suppliers
$6.00/10g
30363-03-2
139 suppliers
$8.00/250mg