2-(4-Bromo-3,5-dimethylphenoxy)acetonitrile synthesis
1synthesis methods
- Product Name:2-(4-Bromo-3,5-dimethylphenoxy)acetonitrile
- CAS Number:951918-29-9
- Molecular formula:C10H10BrNO
- Molecular Weight:240.1
Yield:951918-29-9 535 mg
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 35; for 2 h;
Steps:
1 Step 1:
2-(4-Bromo-3,5-dimethylphenoxy)acetonitrile
Step 1:
2-(4-Bromo-3,5-dimethylphenoxy)acetonitrile
To a solution of 4-bromo-3,5-dimethylphenol (500 mg) and Cs2CO3 (1.3 g) in N,N-dimethylformamide (5 mL) is added 2-bromoacetonitrile (290 μL) and the mixture is stirred for 2 hours at 35° C.
The mixture is poured on water and stirred for 15 minutes.
The precipitate is folitered off and dried to give the title compound. Yield: 535 mg; Mass spectrum (EI): m/z=239 [M]+.
References:
US2013/252937,2013,A1 Location in patent:Paragraph 0470