ChemicalBook CAS DataBase List 2-(4-Chlorophenoxy)-2-methylpropionic acid

2-(4-Chlorophenoxy)-2-methylpropionic acid synthesis

11synthesis methods

Product Name:2-(4-Chlorophenoxy)-2-methylpropionic acid
CAS Number:882-09-7
Molecular formula:C10H11ClO3
Molecular Weight:214.65

637-07-0 Synthesis

637-07-0
226 suppliers
$13.00/500mg

2-(4-Chlorophenoxy)-2-methylpropionic acid

882-09-7
301 suppliers
$5.00/5g

Yield:882-09-7 94%

Reaction Conditions:

with methanol;sodium hydroxide in dichloromethane;water

Steps:

16
Take compound III-2 (1.8g) in a mixed solution of dichloromethane (10mL) and methanol (1mL).10% NaOH aqueous solution (10 mL) was added,The reaction was refluxed for 12 hours.The solvent was distilled off under reduced pressure,Ethyl acetate (10 mL) was added,Adjust pH to acidic with 1N HCl,Ethyl acetate (10 mL x 3) extraction,The organic phase was washed with a saturated saline solution (10 mL x 3),Dried over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure,Compound III-3 was obtained (white solid, 1.5 g, yield 94%).

References:

China Pharmaceutical University;Sun Hongbin;Yan Dingfei;Feng Zhiqi;Zhang Jia;Yao Zhiying;Zhao Wenfeng;Zhang Xiangying;Sun Geng;Han Lishuai;Wu Wenzhen;Liu Shengjie;Zhao Xing;Li Minglei;Yu Shengqi;Chen Hui;Cheng Yalong;Wang Pengfei;Dai Liang;Wen Xiaoan;Liu Jun CN110372638, 2019, A Location in patent:Paragraph 0147; 0149; 0151

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2052-01-9 Synthesis