2,4-Di-Tert-Butyl-6-Chloro-1,3,5-Triazine synthesis
- Product Name:2,4-Di-Tert-Butyl-6-Chloro-1,3,5-Triazine
- CAS Number:73084-03-4
- Molecular formula:C11H18ClN3
- Molecular Weight:227.73
108-77-0
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73084-03-4
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Yield: 95%
Reaction Conditions:
with copper(l) iodide in tetrahydrofuran at 0; for 4 h;Inert atmosphere;
Steps:
1.1 Synthesis of 2,4-di-t-butyl-6-chloro-1,3,5-triazine
Cyanuric chloride (4.18g, 22.7mmol) and copper iodide (0.15g, 0.77mmol) in tetrahydrofuran (23 mL) solution of, Grignard reaction agent (t- butyl magnesium chloride, 0.50M, 91.0mL , it was dropped 45.4mmol) under a nitrogen atmosphere, at 0 . After completion of the dropwise addition, 4 hours reaction was stirred, diluted with saturated aqueous ammonium chloride solution (100 mL), and extracted with diethyl ether. The organic layer was washed with distilled water, dried with sodium sulfate, filtered, and concentrated. The obtained residue was purified by column chromatography (hexane / ethyl acetate = 9: 1) at separation and purification, 2,4-di -t- butyl-6-chloro-1,3,5-triazine (4.89 g, 95% yield). 95% yield, white solid;
References:
Kanazawa University;Kunishima, Munetaka JP2016/160180, 2016, A Location in patent:Paragraph 0173-0176
108-77-0
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$13.00/25g
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73084-03-4
24 suppliers
$285.00/100mg