2,4-dichloro-5-ethyl- 5H-pyrrolo[3,2-d]pyrimidine synthesis
- Product Name:2,4-dichloro-5-ethyl- 5H-pyrrolo[3,2-d]pyrimidine
- CAS Number:129872-82-8
- Molecular formula:C8H7Cl2N3
- Molecular Weight:216.07
![2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE](/CAS/GIF/63200-54-4.gif)
Yield:129872-82-8 90%
Reaction Conditions:
with Cs2CO3 in N,N-dimethyl-formamide at 20; for 24 h;
Steps:
Synthesis of 2, 4-dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine (IIa).
General procedure: A mixture of 2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine (I, 1.20 g, 6.38 mmol)with iodomethane (1.09 g, 7.66 mmol) and cesiumcarbonate (Cs2CO3, 1.04 g, 3.20 mmol) in N,Ndimethylformamide(DMF, 10 mL) was stirred atroom temperature for 24 h (TLC). Then, the mixturewas added ethyl acetate (EtOAc, 40 mL) and washedfive times with saturated saline, the EtOAc was driedover anhydrous sodium sulfate (Na2SO4) and filtered.After removing the solvent under vacuum, the residuewas purified by silica gel chromatography to get compound(IIa) as a yellow solid.
References:
Chuanhui Huang;Wang, Shan;Ma, Weifeng [Russian Journal of Bioorganic Chemistry,2022,vol. 48,# 3,p. 557 - 564][Bioorg. Khim.]
