2,4-difluoro-6-iodophenol synthesis
- Product Name:2,4-difluoro-6-iodophenol
- CAS Number:551002-42-7
- Molecular formula:C6H3F2IO
- Molecular Weight:255.99
367-27-1
346 suppliers
$6.00/5g
551002-42-7
19 suppliers
$130.00/250mg
Yield:551002-42-7 90%
Reaction Conditions:
with iodine;sodium hydrogencarbonate in water at 20; for 24 h;
Steps:
4.2.3 Iodophenols 2; general procedure
General procedure: To a stirred solution of phenol 1 (20mmol) in H2O (40mL), NaHCO3 (2.2g, 26mmol or 4.4g, 52mmol for 2b,e), I2 (5.6g, 22mmol or 11.2g, 44mmol for 2b,e) were added. The reaction flask was closed with rubber septa, in which a needle was inserted and reaction mixture was stirred at room temperature for 24h. Then a saturated aqueous solutions of Na2S2O3 (40mL) was added and the mixture was stirred for 1h. The reaction product was extracted with CH2Cl2 or Et2O (2×100mL). The combined organic layers were washed with saturated aqueous solutions of Na2S2O3 (50mL), H2O (2×70mL), dried (MgSO4), filtered and solvent was removed under vacuum to a constant weight.
References:
Politanskaya, Larisa;Troshkova, Nadezhda;Tretyakov, Evgeny;Xi, Chanjuan [Journal of Fluorine Chemistry,2019,vol. 227,art. no. 109371]
7681-52-9
612 suppliers
$10.00/10ml
367-27-1
346 suppliers
$6.00/5g
551002-42-7
19 suppliers
$130.00/250mg