2,4-DIMETHYL-5-NITROANILINE synthesis
- Product Name:2,4-DIMETHYL-5-NITROANILINE
- CAS Number:2124-47-2
- Molecular formula:C8H10N2O2
- Molecular Weight:166.18
62476-60-2
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2124-47-2
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$12.00/250mg
Yield:-
Reaction Conditions:
with sulfuric acid in ethanol;water
Steps:
2.H.3 3.
3. Preparation of 2,4-dimethyl-5-nitroaniline A mixture of N-(2,4-dimethyl-5-nitrophenyl)acetamide, water (24 mL), concentrated sulfuric acid (12 mL), and ethanol (120 mL) was heated at reflux under an atmosphere of nitrogen for 4 hours. The ethanol was evaporated under reduced pressure and the residue partitioned between ethyl acetate (250 mL) and brine (150 mL). The brine solution was reextracted with ethyl acetate. The combined ethyl acetate extracts were then dried over magnesium sulfate. Evaporation afforded a crude product which was flash chromatographed on silica and eluted with ethyl acetate:hexane (1:4) to afford 4.63 g as a pale yellow solid.
References:
F. HOFFMANN-LA ROCHE AG EP887346, 1998, A2
95-68-1
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$14.00/5g
2124-47-2
130 suppliers
$12.00/250mg
616-72-8
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$45.00/25mg
2124-47-2
130 suppliers
$12.00/250mg