2-[(4-Fluorophenoxy)methyl]morpholine HCl synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: potassium tert-butylate; 18-crown-6 ether / N,N-dimethyl-formamide / 1 h / 140 °C
1.2: 20 h / 140 °C
2.1: hydrogenchloride; 5%-palladium/activated carbon; hydrogen / water; ethanol / 2 h / 760.05 Torr

References:

Fehler, Stefanie K.;Maschauer, Simone;Hcfling, Sarah B.;Bartuschat, Amelie L.;Tschammer, Nuska;Hubner, Harald;Gmeiner, Peter;Prante, Olaf;Heinrich, Markus R. [Chemistry - A European Journal,2014,vol. 20,# 2,p. 370 - 375]