2-(4-Fluorophenyl)morpholine HCl synthesis
- Product Name:2-(4-Fluorophenyl)morpholine HCl
- CAS Number:62243-70-3
- Molecular formula:C10H12FNO
- Molecular Weight:181.21
951626-54-3
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Yield:62243-70-3 130 mg
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 0; for 1 h;Reflux;
Steps:
49 Preparation 49
Preparation 49
2-(4-fluorophenyl)morpholine
To a stirred solution of 6-(4-fluorophenyl)morpholin-3-one (p48, 560 mg, 2.51 mmol) in THF (20 mL), LiAlH4 1 M in THF (3.76 mL, 3.76 mmol) was added drop wise, the resulting solution was then heated at reflux for 1 h.
It was cooled at 0° C. and quenched with Na2SO4 10*H2O until gas evolution ceased.
The suspension was filtered and the salts were washed with EtOAc.
After evaporation of the organic solvent 2-(4-fluorophenyl)morpholine was obtained as yellow oil (p49, 130 mg, y=29%). MS (m/z): 182.1 [MH]+.
References:
US2018/297990,2018,A1 Location in patent:Paragraph 0252
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